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.,BkailyGJacquesDMorphological and functional remodeling of vascular endothelium in cardiovascular diseases.2023;24(3):1998 56

Rats were run in two separate cohorts ( n = 56 per group/wave), where for each experimental test day rats received daily IP injections of vehicle, sCT (3 g/kg), liraglutide (50 g/kg), a combination of sCT and liraglutide (3 g/kg + 50 g/kg) or a stepwise administration of the amylin and GLP-1R analogs (rats received sCT treatment for the first week, liraglutide treatment for the second week, followed by a combination treatment of sCT + liraglutide daily for the remaining two weeks of testing)

The gastrointestinal side effects of Zepbound stem from its mechanism as a GIP/GLP-1 receptor agonist, which slows gastric emptying and alters bowel motility

A 2026 study in The Lancet Obstetrics, Gynaecology, & Women's Health found that combining GLP-1s and hormonal therapy could result in a 35% increase in weight loss

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As a lead compound, 23 (IC 50 = 3.73 M) demonstrates potential for further studies (Figure 4)