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Second, GLP-1R activation enhances neurovascular coupling function, improves cerebral blood flow and repairs BBB integrity, blocking the penetration of peripheral inflammatory factors into the center (Wong et al., 2024)

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Any dose reduction strategy represents off-label clinical judgment and should be discussed with your prescribing physician, who may suggest gradually reducing the dose by one step every 46 weeks based on individual circumstances

Tacelli M, Celsa C, Magro B, et al

Step 4: Enter Your Desired Dose Input your target dose per injection

Tirzepatide achieved superior reductions in HbA1c and body weight compared with once-weekly semaglutide in head-to-head testing. (Del Prato, The Lancet )