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Conclusions Consistent with clinical trials, real-world tirzepatide treatment was associated with greater 6-month weight reduction and more frequent achievement of weight-reduction targets and improvements in select cardiometabolic parameters than semaglutide among adults with obesity without diabetes

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Combining creatine with tirzepatide-based weight loss therapy requires careful consideration of kidney function and hydration status

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Evidence-based GLP-1 telehealth weight loss guides covering eligibility, costs, safety, semaglutide, tirzepatide, and online provider review.

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