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Injection site reactions in the federal adverse event reporting system (FAERS) Post-Marketing database vary among biologics approved to treat Moderate-To-Severe psoriasis

In the SURMOUNT-1 trial at the highest dose, lean mass decreased by 5.67 kg or 10.9% from baseline, with only 25.7% of total weight lost coming from lean mass

June 2024: Mounjaro manufacturer issued an Open Letter warning patients against using the drug for cosmetic weight loss and counterfeit versions of the drug

The same principles apply to tirzepatide and retatrutide, though specific guidelines for retatrutide will not exist until it reaches the market

It targets incretin receptors rather than the hypothalamic-pituitary-adrenal axis

In fact, using the lowest effective dose is the approach most researchers recommend