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Both methods are generally safe when used appropriately, but they differ in nature

HepprichMWiedemannSJSchelkerBLTrinhBStrkleAGeiggesMet alPostprandial hypoglycemia in patients after gastric bypass surgery is mediated by glucose-induced IL-1

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The predicted weight reduction for each cohort was then used to predict the effect sizes for the primary endpoints in the OSA and OA baskets independently, acknowledging that this approach could underestimate weight lossindependent or drug mechanismdependent effects, which may additionally contribute to efficacy