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36 Finally, a cross-sectional study also demonstrated adverse effects of GLP-1 agonists, with patients on exenatide reporting higher PHQ-9 scores (9.70 4.92 vs 6.70 4.66

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Liraglutide has also been reported to cross the BBB to a limited extent, with pharmacologically relevant concentrations detected in discrete regions such as the hypothalamus and brainstem [66,70]

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This article examines the relationship between weight loss injections and fatigue, exploring mechanisms, clinical evidence, and practical approaches to maintaining energy levels during treatment