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When Ozempic binds to the GLP-1 receptors, it enhances the release of insulin in response to high blood sugar, while also suppressing the release of glucagon

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This results in the potential for drug-drug interactions when bupropion is co-administered with drugs metabolized by Cyt 2D6 (which includes many antidepressants, antipsychotics, beta blockers and Class IC antiarrhythmics) (rxlist.com side - drug interactions)