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Strong weight loss outcomes at low doses are both achievable and well established in the literature

It mimics a hormone naturally released when you eat, which helps trigger insulin production and a feeling of fullness, explains Caroline Apovian, MD, codirector of the Center for Weight Management and Wellness at Brigham and Womens Hospital in Boston

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These agents work through local osmotic effects in the colon and are not systemically absorbed to any significant degree

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (Ukpds 34)

GLP-1 agonists are licensed only for type 2 diabetes and obesity, not rheumatoid arthritis or other autoimmune conditions