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However, anaesthetists must be aware that withholding the therapy in patients with type 2 diabetes mellitus may increase the risk of perioperative hyperglycaemia, which can, in turn, elevate the likelihood of postoperative complications, such as wound infections [22]

Clinical evidence supporting the anti-inflammatory effects of GLP-1 receptor agonists comes primarily from cardiovascular outcome trials and mechanistic studies, though most research has examined standard therapeutic doses rather than specifically low-dose regimens

In male Sprague Dawley rats, peripheral administration of Ex4 (30 g/kg, i.p.) reduced spontaneous locomotor activity and significantly attenuated the locomotor-stimulant effects of d-amphetamine (1 mg/kg, i.p.)

doi: 10.1002/mds.29992

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The response to these pharmacological treatments is characterized by distinct phases: an initial period of marked weight loss followed by a gradual slowing until a plateau is reached