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In some cases, improved BP may permit de-escalation of other antihypertensive agents, although this may raise the risk of BP rebound if the GLP-1 RA is subsequently withdrawn

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These are precisely the indications where small molecules have historically delivered some of the most cost-effective therapies, creating a policy paradox: the law designed to reduce drug prices may be diverting innovation away from the most cost-effective modalities

The move addresses bipartisan concerns over pharmaceutical supply chain vulnerabilities, especially those raised during the Trump administration

doi:10.1016/j.bbrc.2014.03.004 52