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Pre-treatment with a GLP1 receptor-blocking antibody neutralised the CNO-dependent improvement in glucose tolerance but did not affect the reduction in food intake, and an independent group of animals pair-fed to the CNO-treatment group demonstrated attenuated weight loss

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Dr Basavaraj GS from Narayana Health City, Bengaluru, explained that the real-world potential of another antidiabetic drug, Semaglutide (popular as Ozempic), was about 5-8%

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