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for severe obesity and Type 2 diabetes, the entry of low-cost generic versions has led to widespread misuse via online pharmacies and wellness clinics.

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Future research is crucial to investigate whether a washout period for GLP-1 agonists before CLN is needed to reduce the risk of AC, if such a risk exists.

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This paper provides a review on the current evidence supporting the use of GLP-1 in experimental animal models and human trials with the ischemic and non-ischemic heart and discusses their molecular mechanisms and potential as a new therapeutic approach.