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METHODS: A cohort Markov model was constructed to compare semaglutide 2.4 mg with the following comparators: no treatment, diet and exercise (D&E), and 3 branded AOMs (liraglutide 3 mg, phentermine-topiramate, and naltrexone-bupropion)

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Research published in the Journal of Clinical Endocrinology and Metabolism demonstrated that drinking 500ml of water increases metabolic rate by approximately 30% for about an hour
