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Abnormalities of the incretin axis have been implicated in the pathogenesis of type 2 diabetes mellitus

GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy), liraglutide (Victoza), and tirzepatide (Mounjaro, Zepbound) have dramatically improved treatment options for Type 2 diabetes and obesity

Conclusion The elucidation of the intricate interactions and impact of DPP-4 on bone is paramount for a proper understanding of the body's mechanisms in regulating bone homeostasis and responses to internal stimuli

Thus, rapid depolymerization for phase I is followed by a requirement for actin polymerization to facilitate sustained ISG release in phase II.

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