tirzepatide action mechanism of (MOA) of Tirzepatide a novel anti diabetic

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For a field defined by a decade of expensive Phase III failures, a single oral, liver-directed, once-daily pill that improved fibrosis on biopsy was a genuine step forward

67, 69 Laverman, G

Similarly, patients with acute pancreatitis, severe kidney disease (eGFR below 15), or untreated diabetic retinopathy require careful evaluation before starting therapy

This finding suggests that the primary mechanism of GLP-1RAs in the retina is likely direct neuroprotection