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Plans include specific titration protocols for gradually increasing doses over 12-20 weeks to minimize gastrointestinal side effects while optimizing therapeutic effectiveness

Ozempic can cause sickness, vomiting, constipation, and tiredness, among other side effects

Seino Y, Terauchi Y, Osonoi T, Yabe D, Abe N, Nishida T, et al

Sambuco, Bradley, et al., 2020), meaning an ROI encompassing the entire structure may dilute detectable effects

GLP-1, GIP, and glucagon receptors

[103] conducted a prospective observational study evaluating 30 RA patients with obesity and T2DM treated with GLP-1 RAs for 6 months, without concomitant conventional or biologic disease-modifying anti-rheumatic drugs (DMARDs)