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Until retatrutide has equivalent data, semaglutide is the evidence-based choice for people with established heart disease

HFpEF and DM share common pathophysiological mechanisms, including systemic inflammation, myocardial fibrosis, endothelial dysfunction, and insulin resistance [3]

[18] [19] Some users report headaches or fatigue during the adjustment period, though there is limited evidence establishing a causal relationship between these symptoms and probiotic use

Frias JP, Davies MJ, Rosenstock J, et al

Their ability to simultaneously address metabolic risk factors, inflammation, and cellular proliferation positions them as one of the most promising drug classes for interrupting SLD progression (Figure 2)

Monitor for insulin resistance and collaborating with the healthcare team to adjust insulin doses