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In clinical trials, tirzepatide led to substantial average weight loss, with higher doses generally producing greater reductions when combined with lifestyle changes

& Mata, J

More recently, rimonabant (developed by Sanofi-Aventis) was approved as a cannabinoid receptor blocker in Europe in 2006, but was removed two years later after serious psychiatric side effects emerged

The main adverse effects were mild gastrointestinal events, mainly on the higher dose (nausea, vomiting, diarrhea, decreased appetite, constipation, and upper abdominal discomfort or pain) [2, 3]

Moderate alcohol consumption is generally acceptable

Side effects often peak at this dose increase, possibly because it represents the largest percentage jump in the escalation (a 50% increase from 5 mg to 7.5 mg)