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The case of Eli Lillys tirzepatide suggests we may be approaching a ceiling in terms of efficacy: aiming for weight loss beyond 20% might be neither necessary nor clinically sound

Effects on glucose metabolism Increased insulin secretion in a glucose-dependent manner Decreased glucagon secretion Increased insulin sensitivity Possible decrease in blood glucose due to the above-mentioned effects

This discouraged researchers from pursuing GIP as a therapeutic target

Head-to-head evidence suggests tirzepatide may produce greater average weight loss in eligible trial populations

Combined anabolic and micronutrient vulnerabilities in these populations may influence musculoskeletal resilience

Efficacy and Safety of a Fixed-Ratio Combination of Insulin Degludec and Liraglutide (IDegLira) Compared With its Components Given Alone: Results of a Phase 3, Open-Label, Randomised, 26-Week, Treat-to-Target Trial in Insulin-Naive Patients With Type 2 Diabetes