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Historically, drug discovery and clinical manufacture have been conservative sectors

PMID: 36977934 3 GLP-1 receptor agonists and delayed gastric emptying: implications for invasive cardiac interventions and surgery

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Continuous semaglutide use produces superior long-term weight loss outcomes compared to intermittent or short-term therapy

Hels et al

One 2024 study at the Smell and Taste Center at the University of Pennsylvania (source) found evidence of GLP1 agonists significantly depressing the perception of all five basic taste qualities. Interestingly, while all participants in the study experienced a slight decline in their sense of smell, it was not considered statistically significant suggesting that olfactory changes may be more individualised, or more complex to detect in standardised tests