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Semaglutide GLP-1 serves as the active ingredient in both Ozempic and Wegovy, wherein Ozempic is predominantly used for the treatment of type 2 diabetes, and Wegovy is approved for weight management

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Emerging multi-agonists such as retatrutide (GLP-1/GIP/glucagon triple agonist) and PTT-A (novel unimolecular peptide tetra-agonist targeting GLP-1, GIP, glucagon and amylin receptors) further expand this concept

However, neither optogenetic nor chemogenetic PPG neuron activation reduced motivated behavior for sucrose in males (51)

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Most patients experience mild nausea, constipation, or bloating during the first few weeks as their digestive system adjusts to this new rhythm