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Drug approval package for application 215256Orig1s011 Wegovy (semaglutide)

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81 Similarly, Chien et al

Chronic ICV administration of oxyntomodulin, a GLP-1R agonist, in mice decreased body weight despite having no significant effects on food intake (Lockie et al., 2012)
Retatrutide has not yet been studied in a dedicated sleep apnea trial, but given its greater weight loss, the expectation is that sleep apnea improvements would be at least as significant as those seen with tirzepatide, possibly more so

doi: 10.1042/CS20110006
