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This includes low expression of low-density lipoprotein receptorrelated protein 1 (LRP-1), a major clearance receptor for A at the BBB (Shibata et al., 2000)

Its also effective in controlling blood glucose levels, making it a dual-purpose treatment for those with both diabetes and obesity

Evidencia cientfica La evidencia disponible sobre tirzepatida en investigacin se concentra en estudios preclnicos en roedores (ratones DIO, ratas ZDF, primates no-humanos) y en ensayos clnicos humanos en contextos regulados (programa SURPASS para diabetes tipo 2, SURMOUNT para obesidad)

The results also demonstrate a significantly higher TH response at four hours than at 24 hours post treatment but the TH level at 24 hours is still about three-fold higher than the untreated control demonstrating consistent activity