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GLP-1 receptor agonists and colorectal cancer risk in drug-naive patients with type 2 diabetes, with and without overweight/obesity

A small molecule oral agonist of the human glucagon-like peptide-1 receptor

While the intraluminal delivery of bile acids stimulated GIP secretion in rats [62], chenodeoxycholic acid (CDCA), one of the primary bile acids and an agonist of G-protein-coupled bile acid receptor-1 (GPBAR-1), attenuated rather than enhanced postprandial GIP secretion in human subjects [63]

5,8 Recent data from an observational Japanese study of oral semaglutide users found that sleeping more than six hours per night and improving sleep quality during treatment were independently associated with greater odds of achieving at least 3 percent weight loss, whereas severe stress, late-night dinner after 9 pm, and sleeping within three hours of dinner were linked with poorer weight loss outcomes