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Biomed Pharmacother 125:109914

Thus GLP-1 was shown to regulate a number of diverse functions: reduction in digestive enzyme secretion, slowing of gastric motility, increases in heart rate and blood flow, increased bone remodeling, and suppression of appetite (via hypothalamic and brainstem nuclei)

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Curr Opin Mol Ther 12:790797 Onge EL, Miller SA (2010) Albiglutide: a new GLP-1 analog for the treatment of type 2 diabetes

Acknowledgments The authors thank the Welch Foundation (Grant AT-1595), American Diabetes Association (Grant 7-07-JF-02), National Institutes of Health (Grant 1 R56 DK080128-01A1), and Juvenile Diabetes Research Foundation (Grant 37-2011-20) for their financial support

Several factors compound the indirect pathways described above, creating significantly higher vulnerability in certain populations