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Cardiovasc Diabetol 20:32 Hundertmark MJ, Agbaje OF, Coleman R, George JT, Grempler R, Holman RR, Lamlum H, Lee J, Milton JE, Niessen HG, Rider O, Rodgers CT, Valkovi L, Wicks E, Mahmod M, Neubauer S (2021) Design and rationale of the EMPA-VISION trial: investigating the metabolic effects of empagliflozin in patients with heart failure
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The ability of -FMH to stimulate food intake is lost in H1R-KO mice (79) and histamines ability to suppress food intake and body weight is reduced in H1R-KO mice compared to control mice (90)
For people whose health doesnt depend on body weight reductions, the potential side effects may be difficult to justify
Losing body fat removes natural insulation, and a leaner physiology requires less energy maintenance, further reducing baseline heat generation
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