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Metformin causes a moderate amount of weight loss over a longer period of time, says Horn

Fat-selective weight loss would be an additional advantage, as the STEP-1 (NCT03548935) trial demonstrated that once-weekly semaglutide 2.4 mg resulted in 3.4 kg (7.5 lb) more loss in lean body mass compared to placebo

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It activates both the GLP-1 and GIP (Gastric Inhibitory Polypeptide) receptors to help control blood sugar and promote weight loss

This approval marks the first FDA-approved oral GLP-1 weight loss pill , which is expected to significantly influence demand in 2026