semaglutide and metformin vs Efficacy safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial semaglutide vs metformina Full article:

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Glucagon suppression (reduces glucose production in the liver)

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45 Conversely, the relative increase in heart rates secondary to GLP-1 RAs may be potentially beneficial in HFpEF due to the high prevalence of chronotropic incompetence in these patients

However, in a contemporary, large, real-world study, 39% of patients receiving GLP-1 receptor agonists did not meet efficacy goals

In 2023, retatrutidea triagonist targeting GLP-1, GIP, and glucagon receptors demonstrated favorable efficacy outcomes in a phase II randomized, double-blind clinical study