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The change in HbA 1c from baseline to week 54 was similar between the two treatment groups (0.51% with sitagliptin and 0.56% with glipizide)

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Nature Reviews Neurology

However, University of Oxford researchers analyzed the results of 37 studies involving more than 9,300 adults

Investigating local administration through phase 1 safety and pharmacokinetic trials is a critical first step to bypass the BRB and maximize retinal tissue exposure while minimizing systemic side effects
