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Dose reduction may be necessary because hepatic excretion is diminished, and zinc can accumulate

These drugs exert their effects by increasing energy expenditure and reducing body weight, by targeting the lateral hypothalamus [52, 111,112,113,114]

And these drugs have been used for diabetes for over a decade so safety is well understood

Wegovy can also cause gastrointestinal side effects in some people, including nausea, vomiting, diarrhoea and constipation, so some supplement choices are really side-effect management rather than weight-loss boosters

So is oral contraceptive effectiveness reduced in endometriosis patients on GLP-1 inhibitors

Of note, these two case subjects had prior history of acute pancreatitis as well