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Without these, reduced appetite becomes a liability rather than an asset

Variants in pharmacokinetic transporters and glycemic response to metformin: a metgen meta-analysis

The exploration of combination with resmetirom, the first FDA-approved agent specifically for MASH, embodies a particularly interesting avenue given the complementary mechanisms of action [71]

Compared to individuals without diabetes, patients with diabetes present a higher atheroma volume, a smaller arterial lumen, more rapid progression of atherosclerosis, more macrophage accumulation, and a higher incidence of thrombus [15, 16]

In a meta-analysis with six studies (three liraglutide studies, three exenatide studies), treatment of GLP-1RAs produced significant improvements in liver histology such as lobular inflammation, hepatocellular ballooning, and fibrosis [78]