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Preclinical studies have indicated that GLP1RAs, such as tirzepatide, may directly impact the vasculature by enhancing endothelial function and decreasing inflammation, which are important in preventing atherosclerosis[30]

A 2025 Bayesian network meta-analysis of 48 RCTs covering 27,729 participants compared GI adverse events across the major GLP-1 RAs.[1] Tirzepatide showed the highest risk of nausea and diarrhea among the agents studied

The changes tend to be subtle initially, with users realizing one day that they have not thought about drinking for several days despite previous daily rumination

(2022, Cell Metabolism) is the pivotal discovery and characterization paper

That third receptor, glucagon, is the key difference

After changing the day, continue using the medication once weekly on the new schedule