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Tirzepatide long-term side effects: what four years of data shows SURPASS-CVOT (Nicholls et al., NEJM 2025) provides the longest-term safety data for tirzepatide a cardiovascular outcomes trial with a median follow-up of approximately four years in 13,165 people with Type 2 diabetes and established atherosclerotic cardiovascular disease

Oral Form (Rybelsus): Due to additional ingredients that may transfer into breast milk, breastfeeding is not recommended while taking Rybelsus

Hindbrain DPP-IV inhibition improves glycemic control and promotes negative energy balance