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Retatrutide represents a potential next-generation obesity therapy targeting multiple hormonal pathways involved in appetite regulation, metabolism, and energy expenditure

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In secondary analyses, we adjusted for additional covariates: Model 2a included age, sex, race-centre (Maryland-White, Minnesota-White, Mississippi-Black, North Carolina-White, North Carolina-Black), smoking status, alcohol consumption (current, former, never), physical activity level (recommended, intermediate, poor), BMI, total cholesterol, HDL-cholesterol, lipid-lowering medication use and hypertension

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Recently, the company published data from a new study that found orforglipron outperformed an oral version of semaglutide, the active ingredient in Novo Nordisks weight-loss peptide