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In global terms, hypothalamic pathways involved in autophagy, neurotransmitter release, cytoskeletal remodeling (RHO GTPases signaling), vesicle-mediated transport and intracellular signaling (PI3K/AKT activation) were upregulated in PWA mice treated with GLP1/E, while pathways related with vesicle transport, oxidative stress, DNA repair, metabolism and immune system were downregulated by GLP1/E treatment (Fig

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[DOI] [PubMed] [Google Scholar] 124.Karlsson O., Thor S., Norberg T., Ohlsson H., Edlund T

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Furthermore, selective CB2 activation reduces M1 macrophages in favor of M2 polarization [114] and increases efferocytosis of apoptotic cells [115]