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If you stop treatment, expect hunger and eating patterns to gradually return to pre-treatment levels over weeks to months

DeVries JH, Desouza C, Bellary S, Unger J, Hansen OKH, Zacho J, et al

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Famously, a trial of more than 5,000 participants with diabetes and either obesity or overweight was stopped after nearly a decade when weight loss of more than 6% failed to improve heart health

This allows isolation of glucagon pathway contributions without the additional GIP variable present in Retatrutide