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MetabolicReproductive Interface Energy Balance and Reproductive Function Reproductive function depends on the integration of energy status with hypothalamic-pituitary-gonadal (HPG) signaling

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The pattern and course of cognitive impairment in late-life depression

We have further shown that this effect could originate from the hypothalamus, as a dual agonist of GLP-1RA with GIP had a synergetic effect in decreasing feeding behavior compared to GLP-1 or GIP alone when delivered to the hypothalamus in an ICV manner [83]

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These drugs work by imitating glucagon-like peptide-1 (GLP-1), a growth hormone that triggers insulin release, reduces blood sugar levels, slows the progress of food along the intestinal track, and stimulates parts of the brain that control craving and satiety