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This multicenter, double-blind, placebo-controlled trial enrolled people with NAFLD with liver fat content at or above 10% by MRI-PDFF, a FibroScan liver stiffness measure below 10 kPa, alanine aminotransferase (ALT) at or below 75 IU/L, and no diabetes or non-insulin-dependent diabetes with A1C below 9.5%

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8 Additionally, a small number of animal and clinical trials have highlighted the benefits of individual GLP-1 RAs, including exenatide and lixisenatide

and 3) increased glucose production by the liver due to augmented gluconeogenesis

However, with growing evidence that the semi-latent form of MSTN also exhibits significant biological activity similar to the mature form,[74] antibody designs were refined to target not only the mature form, but also the latent form and the unprocessed pro-MSTN