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Trial SELECT (Lincoff et al., NEJM 2023) Design Phase 3 / 39.8 mo mean follow-up Population 17,604 adults with CVD + overweight or obesity, no diabetes Key result 20% reduction in major heart events (HR 0.80

How the Study Was Conducted The experiment involved 36 male Sprague Dawley rats divided into four experimental groups: Control (C): Healthy animals receiving no active treatment Streptozotocin (STZ): Animals with induced diabetes but no medication STZ + Retatrutide (STZR): Animals with induced diabetes treated with retatrutide Retatrutide (R): Healthy animals treated with retatrutide Animals in the treatment groups received a daily subcutaneous dose of 0.015 mg/kg of retatrutide for 21 consecutive days