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This cleavage generates the membrane-bound C-terminal fragment CTF99, which is subsequently processed by -secretase to release A peptides of 4042 amino acids (Neha and Parvez, 2023)

N Engl J Med 334:574579 Amori RE, Lau J, Pittas AG (2007) Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis

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