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Mechanisms, pathophysiology, and management of obesity

The study showed that the renal extraction of GLP-1, natriuretic effect of GLP-1 and change of plasma concentrations of ANG II was abolished by the GLP-1 receptor antagonist Exendin 939 (Ex 939), suggesting that GLP-1-induced natriuresis is dependent on GLP-1 receptor activation 38

The factors contributing to bone impairment in individuals with PWS are not fully understood, but possible explanations include loss of function of genes in the q11-q13 region of the paternal copy of chromosome 15, reduced production of sex hormones during puberty, as well as a relative GHD during childhood and adolescence (79)

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A large umbrella review found that GLP-1 receptor agonists are consistently linked to gastrointestinal side effects such as nausea, vomiting and diarrhoea