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Objective To determine whether the use of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with an increased risk of suicidal ideation, self-harm, and suicide among patients with type 2 diabetes compared with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors or sodium-glucose cotransporter-2 (SGLT-2) inhibitors

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Methods Following PRISMA guidelines, a comprehensive search was conducted across PubMed, Embase, CENTRAL, PsycINFO, and Web of Science through April 2025

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Retatrutide is a triple agonist (GIP/GLP-1/glucagon receptor) studied in advanced metabolic research applications

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