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This blog is a straightforward look at tirzepatide, what the research shows, and why so many women are finally seeing results

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Conserved apolar residues in the C-terminal part of GLP-1 (Phe 28 , Ile 29 , Leu 32 ), exendin-4 (Phe 22 , Ile 23 , Leu 26 ), GIP (Phe 22 , Val 23 , Leu 26 ), and glucagon (Phe 28 , Val 29 , Leu 32 ) share a similar hydrophobic interaction site with the ECD of the corresponding receptor (GLP-1R/GIPR/GCGR: L32 ECD /A32/M29, T35 ECD /L35/L32, V36 ECD /Y36/F33, and W39 ECD /39/36 in 1 , Y69 ECD /68/65 in -turn 1 connecting 1 - 2 , Y88 ECD /87/84, L89 ECD /88/85, and P90 ECD /89/86 in -turn 2 connecting 3 - 4 ) (Parthier et al., 2007

Fortunately, GLP1 medications are now FDA-indicated for multiple indications beyond weight management and diabetes, including: Major cardiovascular event (heart attack and/or stroke) risk reduction in adults with cardiovascular disease and overweight or obesity Metabolic dysfunctionassociated steatohepatitis (MASH) Moderate to severe obstructive sleep apnea (OSA) in adults with obesity When one medication can address multiple conditions, it simplifies care and reduces polypharmacy