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Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG, et al

Obesity is on the rise, with rapidly rising rates among adults, adolescents, and children

While not classified as hormonal therapies, these agents can indirectly influence hormonal balance through weight loss and improved insulin sensitivity

When these two medications are taken together, the likelihood and intensity of gastrointestinal side effects can increase

The world of weight management and metabolic health has been transformed by GLP-1 agonists like semaglutide and tirzepatide

Based on the above evidence, we reasonably speculate that GLP-1R-based agonists have potential preventive or even therapeutic effects on MASLD, probably by improving insulin resistance and lipid metabolic disorders