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however, this method increases the risk of maternal malnutrition and obstetric complications, e.g

This genetic-guided approach personalizes treatment selection more rigorously than trial-and-error polypharmacy

GLP-1 drugs, which include medications used to treat type 2 diabetes, obesity, cardiovascular disease, and other conditions, have greatly increased in popularity in recent years due to their demonstrated effectiveness

In late 2025, the FDA approved an oral semaglutide formulation (Wegovy oral) for weight management at 25mg and 50mg doses, with clinical trials showing 13-14% body weight reduction

165,166 The C max and AUC values of ethinylestradiol and levonorgestrel were not affected by the administration of 14 mg oral or 1 mg subcutaneous semaglutide, indicating that it is not clinically relevant (Table 4)