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GLP-1RA Therapy as a Chronic Flux Perturbation System-Level Energy Flux Reorganization Under Weight Loss Therapy Most weight-loss interventionsincluding exercise [49], calorie restriction [50], cold exposure [51], and selected antidiabetic agents [10, 52]ultimately increase reliance on FAO, which supplies acetyl-CoA to sustain tricarboxylic acid (TCA) cycle activity and electron transport chain (ETC)coupled adenosine triphosphate (ATP) production

Conflicts of Interest/Competing Interests The authors declare that they have no conflicts of interest

Tirzepatide has shown greater efficacy in head-to-head studies

References Merikangas KR, Jin R, He JP, Kessler RC, Lee S, Sampson NA, et al

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