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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Vozza A., Triggiani D., Fanelli M., Lisco G., Coletto D., Custodero C., Volpe S., Racaniello D., Colaianni V., Lavarra V., et al

Chronic metabolic conditions are characterized by: Increased production of reactive oxygen species Impaired antioxidant defenses Mitochondrial dysfunction Chronic inflammation Cellular damage to pancreatic -cells, adipocytes, and hepatocytes How GLP-1 Affects Oxidative Stress Research has revealed that GLP-1 receptor agonists exert antioxidant effects through several mechanisms: Direct antioxidant signaling: Activation of the GLP-1 receptor triggers cellular pathways that reduce ROS production Anti-inflammatory effects: Decreases production of pro-inflammatory cytokines that contribute to oxidative stress Mitochondrial protection: Improves mitochondrial function and reduces oxidative damage Endothelial function: Enhances nitric oxide production and vascular health However, during weight loss especially rapid weight loss induced by GLP-1 RAs patients may experience increased oxidative stress due to the mobilization of stored toxins from adipose tissue

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Case report: nerve fiber regeneration in children with melanocortin 4 receptor gene mutation related obesity treated with semaglutide