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Appetite suppression may be mild

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This is important to lower the risk of problems from diabetes, like diabetic retinopathy and kidney disease

In the SURPASS 2 trial, Tirzepatide at all doses (5mg, 10mg and 15mg) was found to result in greater weight loss than semaglutide 1mg

doi: 10.1016/j.metabol.2019.04.014 [DOI] [PubMed] [Google Scholar] 14

The study involved adults with type 2 diabetes and cardiovascular risk, who were randomized to receive tirzepatide (5 mg, 10 mg, or 15 mg) or insulin glargine (100 U/mL) over a treatment period of up to 104 weeks
