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In short, while retatrutide looks highly promising, careful monitoring and more data are needed before it becomes widely available

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Glucagon's capacity to regulate hepatic glucose metabolism is primarily responsible for its hyperglycemic effects [27]

For balance, a 2025 systematic review in Nephrology Dialysis Transplantation that pooled 12 trials with 36,568 participants found no significant overall increase in acute kidney injury (relative risk 0.94)

Am J Physiol Physiol 308:F878F887