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Maintain adequate hydration, monitor blood glucose levels (treating hypoglycaemia if below 4.0 mmol/L), ensure nutritional adequacy with small frequent meals, and rise slowly from sitting or lying positions

A systematic review and meta-analysis of 10 randomized trials totaling 1,030 patients (Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome, Ingrosso, Ianiro, Ford and colleagues, Alimentary Pharmacology & Therapeutics , 2022) found peppermint oil superior to placebo for global IBS symptoms (number needed to treat = 4) and abdominal pain (number needed to treat = 7)

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Tirzepatide, which targets two appetite-regulating hormone pathways simultaneously, achieves closer to 22% on average

In November 2025, the White House announced pricing deals with multiple pharmaceutical manufacturers to lower domestic prices for glucagon-like peptide-1 receptor agonist drugs (GLP-1RAs) including Ozempic, Wegovy, Mounjaro, and Zepbound